In my last Post i explained Bio-informatics as Link-up between
Biology and IT where later came into picture to solve huge data handling problem faced by former at the beginning of the "
genomic revolution", such as nucleotide and amino acid sequences. Development of this type of database involved not only design issues but the development of complex interfaces whereby researchers could both access existing data as well as submit new or revised data.
This field is already popular in west and spread its root but still trying to create impact in India.. This technology has completely rotated the wheel of biological research from conventional wet lab experiments to dry lab(Computer labs).
Now Bio-informatics is not mere alliance of biology and computer science it also includes statistics,mathematics ,various stochastic and non-stochastic probabilities model and Bayesian interference and by collating knowledge from these different branches what
eYE can sEE bIOINFORMATICS is evolved such that the most pressing task now involves the analysis and interpretation of various types of data, including nucleotide and amino acid sequences, protein domains, and protein structures. The actual process of analyzing and interpreting data is referred to as computational biology.Now Bio-informatics is
- the development and implementation of tools that enable efficient access to, and use and management of, various types of information.
- the development of new algorithms (mathematical formulas) and statistics with which to assess relationships among members of large data sets, such as methods to locate a gene within a sequence, predict protein structure and/or function, and cluster protein sequences into families of related sequences.
Covering all these in a single post is impractical and frankly speaking is difficult for me. So we will discuss one by one .i will request you all to please participate in this discussion and input your suggestions and views how Bio-informatics has turned the pages in biological research.
I hope you all are aware duo of
James d Watson and
Francis Crick who, using x-ray data collected by Rosalind Franklin, proposed the double helix structure of the DNA molecule in 1953 and received the 1962 Noble Prize in Physiology and Medicine for their body of research on nucleic acids. In this Pictures it is seen that one of them is standing on small bench to calculate the A:T G:C base pairing so you can imagine that how laborious it was at that time to do all these calculation and keep all records jotted on papers.Similarly take example of structure predictions methods which involves complex calculations which are humanly impossible to keep track of all the data.Likewise Not many people remember those days where people have to wait for almost more than a month period of time to perform single
knock down studies/Over expression studies which currently are matter of minutes by using computational system biology.
Major Research Area in Bio-informatics :
- Sequence Analysis
- Genome Annotation
- Predictions of Protein Structure
- Modeling Biological System
- High Throughput image Analysis
- Protein-Protein Docking
- Drug Designing
- Drug Discovery
- Gene Expression Analysis
This is what eYE sEE in bIO-INFORMATICS and now we are entering in field of bio-informatics where first we will discuss about focus of bio-informatics and then trying to xplore more opportunities in this field..
Thats all for today !!!!!!!!!!!!
will be back with more topics for bio-informatics discussion ...
